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DIAGNOSTIC CRITERIA FOR VITAMIN B12 DEFICIENCY USED IN STUDIES ASSESSING THE VITAMIN B12 STATUS IN PATIENTS WITH T2D ON METFORMIN THERAPY Despite the diagnostic specificities of vitamin B12 deficiency and the necessity to measure biomarkers without suggestive symptoms, most studies assessing the risk of vitamin B12 deficiency in metformintreated patients rely solely on total vitamin B12 levels to confirm the diagnosis

The ribofuranose tetraacetate, shown at the upper left below, was the source of an early puzzle involving polymorphism

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