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281,282,283 In the TME, Gln metabolic reprogramming is essential for the survival of tumor cells and immune cells, and there is competition for Gln uptake

Relative cellular senescence in single and combination treatment condition with respect to DMSO control treated condition is plotted

dissolve platinating agents that are not soluble in water (Fig

Overall, our work demonstrates a key signaling interplay between DA and NE in - and -cells as a novel regulatory pathway for pancreatic hormone release and offers the promise of new therapeutic approaches to treat the dysfunctional secretion of insulin and glucagon by targeting peripheral catecholamine receptors