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They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors

Dysregulated lipid metabolism also promotes aberrant synthesis of pro-inflammatory lipid mediators such as prostaglandins and leukotrienes, thereby sustaining chronic neuroinflammatory states (Johnson and Stolzing, 2019

The molecular docking was performed based on the CB-Dock-2 tool ( CB-Dock-2 is a protein-ligand docking method that automatically identifies binding sites, calculates the center and size, customizes the docking box size based on the query ligands, and then performs molecular docking using AutoDock Vina [17]

[DOI] [PubMed] [Google Scholar] 81.Lau S.S., Zannoni V.G