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doi: 10.5152/eurjrheum.2016.048 124 YangYLinYWangMYuanKWangQMuPet al

The FDA evaluation found insufficient evidence to establish effectiveness for the nominated use and highlighted gaps in physicochemical characterisation, immunogenicity and safety information

As has been reported, HA binding to CD44 enhances proliferation and survival of breast cancer cells through modulating -catenin signaling and nuclear factor-kappa B (NFB)-specific transcription activity and subsequently promoting the expression of P-glycoprotein and B-cell lymphoma-extra large (Bcl-xl) genes in breast cancer MCF-7 cells [63]