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Moreover, fingolimod-induced transient cardiovascular adverse effects must be considered for CIPN prevention and treatment [137]

Genetics contributes meaningfully

Animal studies have revealed that mild to moderate acoustic overexposure, even when causing only a temporary threshold shift (TTS), can immediately and permanently induce cochlear synaptopathycharacterized by the loss of synaptic connections between cochlear hair cells and auditory nerve fibers, without any loss of the hair cells themselves 16,17,18

4e), which is regulated by PPAR and catalyses the rate-limiting step of FAO by converting acyl-CoAs into acylcarnitines allowing their subsequent mitochondrial -oxidation 42