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Trends Mol Med 26(11):975986 Schrimpe-Rutledge AC et al (2016) Untargeted Metabolomics Strategies-challenges and emerging directions

Fertility and Sterility, 92(1), 328-343

Several mechanisms have been reported as responsible for cisplatin resistance, such as reduced drug uptake by a decrease in CTR1 expression, increased efflux by ABC transporters, augmented induction of stress response chaperones, induction of autophagy, inactivation of apoptosis pathway signaling, inactivation by thiol-containing proteins, and functional changes in DNA repair pathways 6,7,8,9,10,11