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doi:10.1080/15563650701261488

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(2) For an ACO that renewed to enter an agreement period beginning on January 1, 2025, to obtain a determination regarding whether the ACO may receive prepaid shared savings, the ACO must submit to CMS a complete supplemental application for prepaid shared savings prior to the start of the performance year beginning on January 1, 2026, in the form and manner and by a deadline specified by CMS

Specifically, rhein has been shown to protect IEC-6 cells from TNF--induced barrier damage by restoring the expression of the TJ protein ZO-1, reducing myosin light chain (MLC) phosphorylation and inhibiting NF-B activation