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Troublesome symptoms of NF1: When to call the doctor If your child has any of the following symptoms, contact their doctor: long-lasting or recurring pain, or pain that wakes your child up or keeps them awake at night numbness, tingling or weakness in an arm or leg changes in neurofibromas, such as persistent and continuous pain, rapid increases in size or hardening problems with vision or bulging of the eyeballs new, lasting or changing headaches

These symptoms often occur at night, while your hands are at rest

This supports traceability and reduces ambiguity essential for clean laboratory work

Kovtunov KV et al (2018) Hyperpolarized NMR spectroscopy: d -DNP, PHIP, and SABRE techniques