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ACS Appl Mater Interfaces (2014) 6(3):195970

10.2174/0929867311320180004 Curr

We demonstrated therapeutic protection of photoreceptor structure and function in a chemically-induced rat model of RP (48% increase in photopic b-wave amplitude), as well as some limited protection in an aggressive genetic mouse model ( rd10 ) of retinal degeneration (~ 31% increase in photopic b-wave amplitude) with once daily application

By examining the promoter regions of HRG, we identified potential HIF-associated higher-order promoter regulatory structures, known as Multiple Organized Regulatory Elements (MORE cassettes)