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For example, miR-98, miR-204, miR-34a, miR-15b, miR-375, miR-140, and miR-335 are involved in the cross talk between mitochondria and oxidative stress (69)

( F , G ) Seahorse XFe96 Mito Stress Test was performed on 4T1 cell line series treated with 2 M UK5099 (mitochondrial pyruvate carrier, MPC, inhibitor), 3 M BPTES (glutaminase 1, GLS-1, inhibitor), or 4 M Etomoxir (CPT1A inhibitor) for 30 min in the presence of standard condition (full medium), and oxygen consumption rate (OCR) was calculated in real-time after the administration of the ATP synthase inhibitor oligomycin, the proton uncoupler carbonyl cyanide p-triflouromethoxyphenylhydrazone (FCCP), and the respiratory complex I inhibitor rotenone together with the respiratory complex III inhibitor antimycin A (Rot/AA) ( F )

Flynn, J

doi:10.1038/s41586-021-03819-2