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doi: 10.1186/s12964-019-0396-5 99 WangXLiYXieMDengLZhangMXieX

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Through its modulation of the NNMT-SAM-NAD+ axis, it enhances energy expenditure and supports more efficient utilization of fat stores for energy, making it a strong candidate in studies exploring metabolic optimization and obesity control

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doi: 10.1016/0092-8674(88)90530-2 33 ChenHLauMCWongMTNewellEWPoidingerMChenJ

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In metformins own drug trials, about 7 in 100 patients who started with a normal B12 level dropped to a low one over roughly 29 weeks

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