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In early vitamin B12 deficiency, when individuals are in negative balance, the amount of vitamin B12 attached to holoTC falls, but there is no concomitant decline in the total serum vitamin B12 concentrations

Journal of hepatology, 56(4), 944-951

More importantly, this interaction enhances the subsequent binding between RGL2 and SLY1/GID2, thereby promoting RGL2s recruitment to the SCF SLY1/GID2 complex for ubiquitination and degradation (Murase et al, 2008

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