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c-Myc increases the levels of glycolytic and PPP enzymes, including LDHA, GLUT1, PKM2, and G6PD [63, 64], and enhances DNL and cholesterol synthesis by transcriptionally activating SREBP1/2 [134]

Further studies showed that iridoids of valtrate, didrovaltrate, and baldrinal upregulated P53 protein expression and downregulated survivin protein expression in MKN-45 gastric cancer cells (Ye et al., 2004, 2007)