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(2) An increased intake of dietary saturated fat, omega-6 fatty acids and trans fatty acids than that of omega-3 fatty acids

P.PettingerM.et al (2022)

During this process, one of the important molecules, HSP70, can bind to Toll-like receptors 4 (TLR4), a type of receptor located on the cell membrane surface, to trigger an inflammatory response and stimulate the body to secrete and synthesize pro-inflammatory cytokines such as TNF- and IL-6, ultimately activating the NF-B pathway and further amplifying the inflammatory response [79]