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However, these natural chemicals present significant therapeutic challenges, including low absorption rates, poor chemical stability, limited permeability, and risk of liver and kidney damage

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Then, the core clock gene BMAL1 has been shown to act as a negative regulator of the target of rapamycin complex 1 (mTORC1), which acts as a master switch between cell anabolic and catabolic programs, thereby suppressing anabolism 82