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In 1928, chemist Edwin Cohn prepared an extract that was 50 to 100 times stronger than obtained from raw liver

37 Dalmatian Dalmatians are reported to have acute hepatic necrosis, chronic hepatitis, and cirrhosis associated with increased hepatic copper concentrations.35, 102 Cholestasis is not a prominent biochemical or histologic feature until later in the disease, suggesting that hepatic copper accumulation is more likely to be caused by a familial metabolic disorder rather than secondary to altered hepatic biliary copper excretion

Renal physiology 301, F134-150, doi:10.1152/ajprenal.00033.2011 (2011)

10.1111/jfbc.13375 J Food Biochem