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In contrast, a secondary analysis of the Nutritional Prevention of Cancer showed, for the first time, an increased risk of type 2 diabetes mellitus in healthy subjects who received 200 g/d of Se for an extended period (Reference Stranges, Marshall and Natarajan9)

This accumulation of reactive oxygen species (ROS) disrupts meiotic spindle assembly, impairs spindle assembly checkpoint signaling, compromises chromatin cohesion, and ultimately deteriorates oocyte quality and developmental potential in women of advanced reproductive age (17)

This is primarily due to the upregulation of phagocyte NADPH oxidase activity, which is a potent producer of superoxide ions (Vermot et al., 2021)

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