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8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

A 2023 crossover trial in fatigued office workers found 500 mcg daily for 8 weeks slashed fatigue scores by 25%, linked to optimized homocysteine metabolism