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Materials and Methods Database Curation A database of 2381 FDA approved drugs was obtained from DrugBank (Approved Drugs, Version 5.1.1, released 3 rd July 2018) in Simplified Molecular-Input Line-Entry System (SMILES) format [20, 21]

Building upon this knowledge base, NanoSU6668 was encapsulated by mesenchymal stem cells (MSCs) derived MVs [28,29,30,31]

The interaction and co-localization of GSTP1 and STAT3 were detected using co-immunoprecipitation (co-IP) and immunofluorescence (IF) in the SW620 cell line