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In diabetic wounds, hypersecretion of IL-1 promotes degradation of the matrix through activation of matrix metalloproteinases and inhibits the activity of the fibroblast, further delayed the tissue regenerative process

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doi: 10.1186/s12870-014-0264-9 274 ZhangJ

Overall, these findings underscore that metabolic, cardiovascular, and other comorbid conditions significantly amplify HCC risk in CHB infection, both independently of alcohol and in combination with it