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For references and more information , see the section on cardiovascular disease in the Fiber article

Thus, the distinctive nutritional needs associated with a disease reflect the total amount needed by a healthy person to support life or maintain homeostasis, adjusted for the distinctive changes in the nutritional needs of the patient as a result of the effects of the disease process on absorption, metabolism, and excretion. It was also proposed that in patients with certain disease states who respond to nutritional therapies, a physiologic deficiency of the nutrient is assumed to exist

Although some key mechanisms have been identified, such as mitophagy, mitochondrial dynamics, and mitochondrial biogenesis, their interactions and regulatory networks require further exploration