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Given that glutamine metabolism increases the amount of GSH in cells by maintaining the NADPH/NADP + ratio and by preventing export and extracellular degradation of GSSG, glutamine is the primary amino acid that controls cellular GSH homeostasis

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Public comments supportive of including the measure in the Hospital VBP Program noted the measure is CBE endorsed and that it encourages hospitals to follow published international guidelines for the early identification and management of severe sepsis and septic shock

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