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One of the lesser-known of the four enzymes is GGT, or Gamma-Glutamyl Transferase

For example, taking very high doses of vitamin B6 can lead to potentially irreversible nerve damage over time, while taking large amounts of niacin typically in excess of 2 grams per day can cause liver damage ( Fat-soluble vitamins Unlike water-soluble vitamins, fat-soluble vitamins do not dissolve in water and are easily stored in your bodys tissues ( There are four fat-soluble vitamins: Vitamin A Vitamin D Vitamin E Vitamin K Given that fat-soluble vitamins can accumulate in the body, these nutrients are more likely to lead to toxicity than water-soluble vitamins

Several studies reported that SP displayed protective effects in rats liver and kidney against toxicities through upregulation of the SIRT1 expression 28,29