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In the OPC-like compartment, NTRK2 expression correlated with postsynaptic organization, axon guidance, neuronal projection guidance, neuronal migration, ERK signalling cascades and the AKT signalling cascade, consistent with the hypothesized role of TrkB in neuron-to-glioma synapses, consequent effects of AMPAR-mediated synaptic signalling on tumour migration 29 and expected signalling consequences of TrkB activation

Last, all patients were prescribed azathioprine from the beginning, making it impossible to differentiate azathioprine hepatotoxicity from non-response [186]

Abbreviations Anti-Tg: Anti-thyroglobulin antibody Anti-TPO: Anti-thyroid peroxidase antibody D1: Type 1 iodothyronine deiodinase D2: Type 2 iodothyronine deiodinase D3: Type 3 iodothyronine deiodinase fT4: Free thyroxine GPx: Glutathione peroxidase HPT axis: Hypothalamicpituitarythyroid axis IFN-: Interferon gamma IL-6: Interleukin-6 ROS: Reactive oxygen species SCH: Subclinical hypothyroidism Se: Selenium T3: Triiodothyronine T4: Thyroxine TNF-: Tumor necrosis factor alpha TRH: Thyrotropin-releasing hormone TSH: Thyroid-stimulating hormone Zn: Zinc References Monzani A, Prodam F, Bellone S, Bona G (2015) Subclinical hypothyroidism

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