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This aligns with the clinical correlates observed by Shrestha et al., which indicate that high baseline redox scores predict poor immunotherapy responses [306]

NLRP3 is an inflammasome, and its activation is closely related to tumorigenesis and tumor-related inflammation (35)

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Lpez-Mirabal H.R., Winther J.R

In prokaryotes, this intermediate is subsequently reduced with NADPH to hydroxybutyryl-CoA by acetoacetyl-CoA reductase, and hydroxybutyryl-CoA may then be polymerized to form PHB by the enzyme PHB synthase (Anderson and Dawes, 2011