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Animal studies have reported observations of altered body composition and reduced adiposity in NNMT-inhibited models

In 2023, Lopez-Otin proposed twelve markers of aging, including genomic instability, telomere loss, epigenetic changes, loss of protein balance, failure of macroautophagy, dysregulated nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell depletion, altered intercellular communication, chronic inflammation, and dysbiosis

[32:55] You still need fat in your diet, but a lot of people are still afraid of it