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However, a growing body of evidence reveals a pronounced immunoinflammatory phenotype in OA, wherein macrophages, T/B lymphocytes, and inflammatory factors such as IL-1, TNF-, and IL-6 play a critical role in the local microenvironment ( 4.1 The role of immune cells in the local microenvironment of OA Macrophages are among the most prominent immune cells within the OA synovium

Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6

This observation suggests that Frag 176-191 might elevate levels of these receptors in adipocytes

Moreover, these expected proteasomal substrates enable proteome-wide screening of candidate proteins using quantitative proteomics from cell lysates