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In patients with ME/CFS and Long COVID, advanced neuroimaging studies have consistently demonstrated abnormally low levels of brain glutathione coupled with highly elevated levels of ventricular lactate, a clear indicator of neuroinflammation and mitochondrial distress

Under normal physiological conditions, NRF2 binds to Kelch-like ECH associated protein 1 (KEAP1) and is inactivated through proteasome-mediated ubiquitination degradation

Clinically, anticholinergic drugs are often used in combination with L-DOPA or dopamine receptor agonists, primarily for the treatment of PD patients with tremor [132]

This interaction was associated with improved remyelination after experimental demyelination in mice, and may be a way by which microglia prevent neuronal damage from hyperactivity (Madry et al., 2018