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Such RNA interfering agents include, but are not limited to, nucleic acid molecules (including RNA molecules homologous to a target biomarker gene or fragment thereof encompassed by the present invention), short interfering RNAs (sirnas), and small molecules that interfere with or inhibit expression of a target biomarker nucleic acid by RNA interference (RNAi)

10.1159/000492091 171 SinghN.GuravA.SivaprakasamS.BradyE.PadiaR.ShiH.et al (2014)

C/EBP knockdown, for instance, decreased expression of all genes measured, including ATF4, which was also reflected in loss of ATF4 protein (Figure 2C-D)

Immunotherapy is powerful, but it can be very hard on the body