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Additional information Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

There may be instances where certain conditions, such as poor nutrition, intestinal issues, infections, and cancer, may lead to B12 deficiency

The therapeutic effects of BPC-157 are exerted through multiple courses of action

Second, the mechanism by which different GRKs polymorphisms affect enzymatic activity remains still unknown, which may be related with the crystal structure of GRKs polymorphisms