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THC directly activates cannabinoid receptors CB1R and CB2R to produce its pharmacological actions, whereas CBD is thought to be an indirect agonist that boosts endogenous concentrations of the endocannabinoids like AEA via inhibition of fatty acid-binding proteins (FABPs) [34], such as FABP5 and FABP7 [35]

or current smoking habits exceeding 10 cigarettes per day were excluded

Glutathione S -transferases: the first enzymatic step in mercapturic acid formation

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