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In order to validate this dopamine-depletion model, we had animals from both vehicle and AMPT groups placed in open-field chambers on three consecutive days to record their baseline locomotor activity

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Epithalon, Melatonin, and Circadian Regulation Because Epithalon is associated with pineal and circadian research, its impact on melatonin-related pathways has received particular attention: Rat studies suggest that Epithalon may influence both synthesis and release of melatonin by modulating AANAT and pCREB-related transcription factors, which play central roles in the melatonin production pathway

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