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Comment: Many commenters supported our proposal to exercise our authority in section 1861(pp)(1)(D) of the Act to expand our approach to a complete CRC screening at 410.37(k) to add a Medicare covered blood-based biomarker CRC screening test (described and authorized in NCD 210.3) alongside the Medicare covered non-invasive stool-based CRC screening test within the definition of a complete CRC screening. Commenters appreciated CMS' recognition that CRC screening would not be complete with a positive blood-based biomarker test alone and noted that a positive test requires a follow-up colonoscopy to confirm the presence of polyps and/or cancer

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It was shown to have multiple sites of action