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Clin Diabetes Endocrinol (2018) 4:9

Other research with RA patients in Italy showed a strong correlation between inflammation, oxidative stress, and lowered glutathione levels in the bloodstream

24 With respect to this, the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study may indicate that activity of the de novo thymidylate synthesis pathway is increasingly impaired in populations exposed to higher UVR, but the burden of this variant is unclear due to mSHMT likely maintaining cSHMT activity in such cases

Beyond disulfide bonds, diselenide bonds (-SeSe-) have also been employed in GSH-responsive DDSs, owing to seleniums chemical similarity to sulfur, as both elements belong to Group VI of the periodic Table [58]