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Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis

Mesenchymal stem cells (MSCs) have attracted considerable interest in recent years

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Are all 15 amino acid residues required for cytoprotective activity, assuming there is a quick, reliable in vitro assay available