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Interestingly, endoglin blocking antibodies downregulated VEGF expression [100] and it has been shown that anti-VEGF therapy upregulates endoglin expression in a preclinical model, indicating that endoglin is implicated in anti-VEGF therapy resistance [97]

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Parameters to monitor History of depression (reserpine) Sleep disturbances, drowsiness, and lethargy (reserpine) Symptoms of peptic ulcer (reserpine) Centrally active 2 -agonists See Table 12-10 for a list of centrally active 2 -agonists, their usual dosage range, and adverse effects associated with these medications