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Furthermore, by blocking the PI3K/Akt/mTOR signaling pathway, deltonin could also reduce the expression levels of important DNA-repair enzymes, such as Rad51 and murine double minute (MDM)2 (155)

While not one of the more severe GHK-Cu contraindications, its a safety factor to consider, and any use should start at a very low dose with careful monitoring for dizziness or lightheadedness