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The latter binds to RAGE, leading to an increase in NF-B-dependent pro-inflammatory gene expression, suggesting that CML-S100A8/S100A9 generated in inflammatory lesions can elicit a RAGE-dependent inflammatory response (129)

This suggests that immune dysregulation, in the form of a shift toward autoimmune responses, may contribute to on-going synovitis following antibiotic treatment in the joint (146)

What to track in a symptom diary Timing, duration, activity when it starts, affected fingers, neck/shoulder positions, associated symptoms (chest pain, shortness of breath), and response to rest or meds