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Acknowledgements We would like to thank Seung-Jae Lee (Korea Advanced Institute of Science and Technology) and Alex Mendenhall (University of Washington, USA) for useful discussion, Fangjia Zhao for assistance with transmission electron microscopy, Yimu Fan, Wanlin Sun, and Yihan Wu for other minor research contributions, and Liesbeth Temmerman (Leuven University, Belgium) for providing strains

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7.1 Neutrophil-derived exosomes: molecular engines driving the NETosis cascade and microcirculatory dysfunction As the vanguard of the innate immune system, the role of neutrophils in sepsis-associated ARDS has transcended simple pathogen clearance

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