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Supplementation (typically 500-2000 mg daily) can boost its effects

Less Common Side Effects Allergic reactions Increased hunger Water retention Joint pain IGF-1related therapies: hypoglycemia (including severe), tonsillar hypertrophy, intracranial hypertensionrequire close medical supervision

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Recently, it has been used exogenously to improve plant tolerance to a wide array of abiotic stresses, including drought, salinity, alkalinity, heavy metals and heat stress (Ramadan et al., 2022