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The oxidation state of the Co centre (as absorbed from the gut) is 3+ as in hydroxocobalamin, although reduced states, such as the 2+ or 1+, are known to be biologically relevant and well tolerated

Its lipolytic activity proceeds through the beta-3 adrenergic receptor pathway instead

Before starting folic acid, your GP will check your vitamin B12 levels to ensure they are normal, as folic acid can sometimes mask an underlying B12 deficiency.

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