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Mice were injected intraperitoneally (i.p.) with 15 mg/kg Escherichia coli O111:B4 LPS (Sigma-Aldrich)

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In a clinical trial conducted by Rhodes [77] on 16 healthy white volunteers exposed to a UV simulator composed of UVA and UVB radiation sources to induce skin photoaging damage, it was found that oral administration of GTE containing 40.3% EGCG and vitamin C for 12 weeks effectively inhibited UV irradiation-induced skin inflammation and that the level of inflammatory mediator 12-hydroxyeicosatetraenoic acid was reduced while PGE2 did not change

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