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and (5) any severe adverse neurodevelopmental effects might be attributed to the indication for the drug.Most clinicians and caregivers are not currently aware of the available knowledge concerning apparent adverse reactions to early APAP exposure in susceptible children

If clinical improvement is absent, if there is a history of prolonged supplementation, or if semen parameters deteriorate despite treatment, it may be necessary to reassess antioxidant therapy and consider investigating RS [72]