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Abnormalities in mitochondrial structure and defects in mitophagy have been identified in the neurons of patients with sporadic ALS (Rodriguez et al., 2012

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Surprisingly, postsynaptic currents were enhanced in layer 2/3 RSG neurons (2-3 days after a single dose of a 5-HT2A receptor agonist, similar to PFC neuroplasticity) despite no receptor expression of 5-HT2A in this region