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This results in conformational flexibility of the crossover loop as in the ubiquitin bound structure the crossover loop is displaced away from ubiquitin to make space for the C-terminal tail to thread into the active site ( Figure 6 , red loop)

89 KessarisN.FogartyM.IannarelliP.GristM.WegnerM.RichardsonW

Notably, many MBP + fibers also stained for human-specific markers for mitochondria and STEM121, indicating that graft-derived OLs were functional and actively producing myelin (Palma-Tortosa et al., 2020)