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Duodenal cytochrome B (DcytB), potentially in concert with other reductants, ultimately reduces Fe + to ferrous iron (Fe + )

Particularly promising are agents that integrate complementary mechanisms, simultaneously mitigating neuroinflammation, counteracting oxidative stress, and preserving synaptic integrity, to address the diseases multifactorial nature [33, 34]

Experimental Section Materials 1-Methylnicotinamide chloride, glutathione, and all other chemicals were purchased from Sigma-Aldrich (Saint Louis, MO, USA) and used without further purification

To offer viewpoints on policy, access, and ethical oversight, government and regulatory documents from organisations such as the Malaysian Ministry of Health and the US Food and Drug Administration (FDA) were included