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Age-related changes in circadian regulation of the human plasma lipidome

10.1152/physrev.00007.2015 3 BocaS

Nutr Rev 81(9):12251233

A literature review published in 1992 reports hepatotoxicity in six patients from unmodified niacin, two patients from sustained release and in 10 patients after changing from unmodified to time-release preparations, likely due to ingesting time-release niacin at doses well above the usual therapeutic doses [12]