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10.1038/s41598-022-17046-w 46 CunninghamJ.M BriggsA.CottrellE.DoyleF.DziedzicK.FinneyA.et al (2021)

Its largely due to the treatments (antiretroviral therapies), which can lead to a preferential accumulation of visceral fat through a mix of mechanisms, including causing mitochondrial dysfunction and insulin resistance

The precise location of this insertion along the sequence allows us to explain the deleterious effects of a mutant in this region and suggests new functional studies