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After demonstrating the transcriptional augmentation of SIRT3 by Rd, C-C and Compound A (C-A) were employed to inhibit AMPK and ERR respectively, and the treatment blocked the enhancing effects of Rd (Fig

Additionally, the diet reduces amyloid- plaque deposition and microglial overactivation in Alzheimer s model mice, providing a novel mechanism for intervening in neurodegenerative diseases through regulation of metabolic enzyme modifications (Han et al., 2025)

GFRAL-expressing neurons suppress food intake via aversive pathways

When NAC was given alone, it accelerated senescence and shortened the lifespan of the nematode worm Caenorhabditis elegans [27]