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Defects in carnitine cycle, in very long chain-, long chain-, medium chain-, short chain dehydrogenases and in the electron transfer pathway cause different forms of FAODs, which require different nutritional (low-fat diet and medium chain triglycerides administration in some long chain FAODs) and therapeutic approaches or no approach

Conversely, PHGDH knockdown or inhibition of its enzymatic activity leads to ROS accumulation and induces oxidative stress-mediated death in HCC cells ( 3.3 Shaping the immunosuppressive tumor microenvironment Metabolic reprogramming represents one of the core hallmarks of malignant tumors

Clinical Toxicology , 60 (4), 507513